TEORI-BIOFIKSIKA
Biofisika adalah sub-disiplin dari Ilmu Biologi yang mempelajari kaidah-kaidah fisika yang mendasari proses sistem kehidupan.
Biofisika adalah sains reduksionis Karena secara filosofis biofisika meyakini bahwa semua fenomena yang teramati di alam dapat dijelaskan dan diramalkan secara saintifik.
Menurut tafsiran reduksionis jika sebuah fenomena alam tidak dapat dijelaskan saat ini, tidak berarti fenomena tersebut tidak akan dapat dijelaskan di masa mendatang. Ketidak tahuan kita akan fenomena tersebut karena kita tidak memiliki perangkat yang memadai untuk mempelajari penyebab yang mendasari fenomena tersebut. Meskipun demikian, ada persoalan-persoalan yang dianggap para Ilmuwan tidak akan pernah dipecahkan sains, misalkan soal ukuran dari Alam Semesta.
The
life is a function of state that depends on stochastic processes at
microscopic level (microphysical laws) and deterministic processes at
macroscopic level (macrophysical laws). The biophysics' subjects of
study are both, stochastic and deterministic processes.
A
stochastic system is a system whose microscopic states have random
underlying causes. A deterministic system is a system whose microscopic
states have knowable underlying causes.
Biophysics
is not a branch of physics, but of Biology. I make this clarification
because in many books of biophysics it is said that biophysics is the
study of the biological processes from the point of view of physics,
which is erroneous because the physics is not limited to the study of
the biological processes but of the processes taking place in the whole
nature. Biophysics explains the biological phenomena applying physical
principles.
BIOLOGICAL SYSTEMS
In general, a system is an amount of matter contained by real or imaginary limits.
In
biophysics, the same as in thermodynamics and quantum mechanics, a
system is an aggregate of elements integrated into real or imaginary
limits.
The
difference between the concept of system in thermodynamics and the
concept of system in biophysics is that thermodynamics considers a
system like a conglomerate of matter, whereas biophysics considers a
system as the aggregates of matter with a set of functions that compose a
process within structural and space/time limits.
A
thermodynamic system is one that can exchange heat and energy with the
environment. The living beings are essentially thermodynamic systems.
For example, an ant is a system made of diverse kinds of molecules,
while the nervous functions of that ant constitute a system formed by
autoregulated sequences of microphysical processes.
The systems can be classified into the following types:
Open systems, which interchange matter and energy with the environment.
Closed systems, which only interchange energy with the environment, but not matter.
Isolated
systems, which do not interchange energy and matter with the
environment. The isolated systems are idealizations which do not exist
in the real world.
The living beings are true-open systems because they interchange matter and energy with the environment.
THERMODYNAMICS IN BIOPHYSICS
Introduction
In
view of the fact that bionts are thermodynamic systems, they are
governed by the same physical laws by which the inert matter is
governed. The formulas on heat transfer which are applicable to the
processes in inert systems also are appropriate for biosystems. Thus,
the laws that we have learned in papers like heat transfer and heat stored by greenhouse gases are also functional for biosystems.
The
paths of heat transfer in biosystems are exactly the same paths that
happen in the abiotic nature (abiotic means lifeless). Consequently, we
can apply to biosystems’ thermal processes the same mathematical
procedures and physical laws that we use for studying the inert matter.
Let
us deal first with the definitions of the laws of thermodynamics and
the concepts and formulas used in heat transfer science.
1. LAWS AND GENERAL FORMULAS:
1st Law of Thermodynamics: Energy can be changed from one form to another, but it cannot be created or destroyed.
The mathematical expression of the 1st. law is as follows:
ΔU = ΔQ – ΔW
Where ΔU is the increase of the internal energy of a thermodynamic system, ΔQ is the amount of heat applied to the thermodynamic system, and ΔW is the change of work done by that thermodynamic system.
The
formula means that the change in the internal energy of a system is
equal to the heat transferred to that system minus the work done by that
system in its environment.
2nd Law of Thermodynamics:
In all transformations from one form of energy into another form of
energy, a quantity of energy is always dispersed towards other states,
generally in the form of heat.
The mathematical expression of the 2nd law is as follows:
ΔS/Δt ≥ 0
Where ΔS is the increase of the entropy, and Δt is time.
The
formula denotes that the change in the entropy in a thermodynamic
system is always higher or equal to zero, and that time is the
fundamental dimension in which the system is doing work.
The formula permits us to deduce other conceptualizations of the 2nd law which mean the same thing, for example:
1. No system can transform energy into useful forms of energy with an efficiency of 100 percent.
2. Energy cannot spontaneously rearrange from low density states to high density states.
3. Heat is never spontaneously transferred from cold systems to hot systems.
2. GENERAL FORMULAS TO CALCULATE THE FLUCTUATIONS OF TEMPERATURE:
CONDUCTION is the flow of heat through solids and liquids by vibration and collision of molecules and free electrons.
The molecules of a portion of a system at a higher temperature vibrate
faster than the molecules of other regions of the same -or of another-
system at lower temperature. The molecules with a higher movement
collide with the molecules less energized and transfer part of their
energy to the less energized molecules of the colder regions of the
structure. For example, the energy transfer by conduction through the
bodywork of a car.
Metals
are the best thermal conductors; while non-metals are poor thermal
conductors. For comparison, the thermal conductivity (k) of the copper
is 401 W/m*K, while the thermal conductivity (k) of the air is 0.0263
W/m*K. The thermal conductivity of the carbon dioxide (CO2) is 0.01672
W/m*K, almost the thermal conductivity of an isolator.
Formula to calculate the conductivity gradient for a given system:
q = - kA (Δ T/Δ n)
Where Δ T/Δ n is the temperature gradient in the direction of area A, and k is the thermal conductivity constant obtained by experimentation in W/m.K.
CONVECTION is the heat transfer through currents within a fluid (a
liquid or a gas). Convection is a movement of liquid or gaseous
volumes. When a mass of a fluid warms because it is in contact with a
hot surface, its molecules are expanded and scattered causing that the
mass of that fluid becomes less dense. As the hotter volume of the fluid
becomes less dense, it will be displaced vertically and/or
horizontally, while the less hot but denser volumes of the fluid will
sink (the less hot volume is displaced by the hotter volume of fluid).
By this mechanism, the hotter volumes transfer energy towards the less
hot volumes of that fluid (a liquid or a gas).
For
example, when we heat up water on a stove, the volume of water at the
bottom of the pot will be warmed up by conduction from the metal of the
pot and it will become less dense. Then, because it is less dense, it
will shift upward to the surface of the volume of water and will
displace to the upper -less hot and denser- mass of water.
Formula of Convection:
q = hA (Ts - T ∞)
Where h is the constant for the convective heat transfer coefficient, A is the area implied, and Ts - T∞ is the difference between the temperature of skin (Ts) and the temperature of the flowing fluid (T∞).
To calculate the convective heat transfer coefficient of the skin we use the next formula:
h = (8.3 W/m^2 K) [(v air (0.6 s/m)]
Where vair
is the velocity of air (m/s) and 0.6 s/m is a proportionality constant.
For example, if a clothed man is surrounded by air which velocity is
0.5 m/s, the convective heat transfer coefficient (h) of his skin would
be:
h = (8.3 W/m^2 K) [0.5 m/s (0.6 s/m)] = 8.3 W/m^2 K (0.3) = 2.49 W/m^2 K
RADIATION is the transfer of heat by electromagnetic radiation.
It does not need a propagating medium. Radiated energy moves at the
speed of light. The thermal energy radiated by the Sun can be exchanged
between the solar surface and the Earth's surface without heating the
transitional space.
For
example, if I place an object (such as a coin, a car, or myself) under
the direct sunbeams, I will note in a little while that the object will
be heated. The exchange of energy between the Sun and the object occurs
by radiation.
Living
beings are good emitters and absorbers of radiant energy. For example,
the skin of a white human being has an emissivity of 0.7 - 0.9,
depending on the pigmentation of the skin; bronzed skins absorb and emit
more energy than white skins.
The formula to know the amount of heat transferred by radiation is:
q = e σ A [(ΔT)^4]
EXAMPLES IN THE HUMAN BODY
The rate of thermal energy storage in form of internal energy of the human body is defined by the next formula:
q = M – W – E – Q = W/m^2
Where q is the rate of energy storage of human body, M is the metabolic rate of human body in Mets (58.2 W/m^2 = 1 Met), W is the mechanical work produced by the human body, E is the rate of total evaporative loss due to evaporation of sweat, and Q is the total rate of energy loss from the skin (not including sweat).
For knowing the linear flux of energy (JQc) under the mentioned conditions, we use the next formula:
JQc = - λ (∆T / ∆x)
Where λ is the thermal conductivity (thermal coefficient) in J/m s K, ∆T is the difference of temperature between two systems, and ∆x is the direction of the temperature gradient.
There
are several channels of heat transfer between the human body and its
environment. Some channels end in the corium, internal with respect to
the epidermis; other channels “cross” muscles, fat layer, epidermis and
hair, until reaching the interface or viscous boundary layer, which
connects the body system with the environment and where the thermal
energy is transferred to the surrounds by conduction, convection,
radiation and evaporation, if the body is within air, or by conduction,
convection and radiation, if it is submerged in water.
For
example, the energy transferred by conduction can reach directly to the
interface or viscous boundary layer. The energy transferred by
convection can diffuse only to the layer of fat; however, the heat
insulated by the layer of fat is transferred through conduction out to
the interface (viscous boundary layer) where it will start again the
channel of convection and radiation for being diffused to the surrounds.
On the other hand, the energy transferred by radiation begins in the
epidermis, not in the inner tissues, and it is radiated directly towards
the environment.
For
calculating changes of the internal energy of a biosystem we use the
fundamental Gibbs' formula. Gibbs’ formula permits the calculation of
the differential of the internal energy (dU) of a biosystem (any living being), which is determined by several differentials that are translated into work:
m
dU = T dS – p dV + Fdl + Σ μi dni + ψ dq
i=1
Where T is the temperature of the system, dS is the local entropy of the system, -p is the compression pressure, dV is the differential of volume caused by the compression, F is a given force exerted on the system, dl is the differential of elongation or size change, m is a determined number of molecules, i is a unit vector in a given direction, μi is the chemical potential of the unit vector, dni is a certain number of atoms or molecules, ψ is an electrodynamic potential and dq is any amount of electrical charge.
We
could say that the Gibbs’ fundamental equation is the equation of life,
of such form that we could determine whether a system is biotic or not
by simply trying to apply the formula on the work (W)
done by that biosystem and on the amount of heat used by that system
for doing work. Any of the Gibbs’ fundamental equation parameters can be
adjusted by expanding or reducing them according to the studied
bioprocess or to the biosystem’s physiology.
HEAT FLUX DUE TO CONDUCTION BETWEEN THE HUMAN BODY AND ITS ENVIRONMENT.
As we have learned in the previous section, the formula to know the linear flux of energy due to conduction is as follows:
JQc = - λ (∆T / ∆x)
Known data:
λ (thermal coefficient) of human epidermis and corium = 0.34 J/m s K
T of surrounds = 315.65 K (42.5 °C)
T of the human body = 306.15 K (33 °C)
∆T = 9.5 K
∆x = 0.01 m (averaged thickness from bone to the viscous boundary layer)
Introducing magnitudes:
JQc = - 0.34 J/m s K (9.5 K / 0.01 m) = - 323 J/s
Then
the load of heat flux by conduction between the human body and the
surroundings is - 323 J/s. The negative sign means that the energy flux
is from higher to lower temperature, in this case from the surroundings
(warmer) to the human body (colder).
When
we investigate the human body, we use the value 0.7 like the
absorptivity-emissivity of the human body because it is a gray body.
In
14 September 2008 at 11:00 UT , the ambient temperature was 20 °C. The
temperature of my left forearm skin was 31.4 °C. What is the heat flux
between my body and the environment?
HEAT FLUX DUE TO RADIATION BETWEEN THE HUMAN BODY AND ITS ENVIRONMENT.
To know the flux of energy transferred from the body to the environment due to radiation we would use the next formula:
q = 0.7 (A) (σ) (Tsur^4 - Thb^4)
Where
0.7 is the absorptivity- emissivity of the real human body (because it
is a gray body. The value changes depending on the pigmentation of the
skin), A is the area of exchange of heat, σ is the Stephan-Boltzmann constant (or proportionality constant = 5.6697 x 10^-8 W/m^2 K^4), Tsur is the temperature of the environment surrounding the body, and Thb is the temperature of the human body.
For
example, let’s suppose an adult (body surface = 1.9 m^2) in an
environment at 20 °C and with a skin temperature of 31.5 °C. First of
all we should convert Centigrades to Kelvin:
Absolute temperature of environment = 20 °C + 273.15 = 293.15 K
Absolute temperature of the human skin = 31.5 °C + 273.15 = 304.65 K
A = 1.9 m^2
Introducing magnitudes:
q = 0.7 (1.9 m^2) (5.6697 x 10^-8 W/m^2 K^4) ([293.15 K]^4 - [304.65 K] ^4) = - 92.66 J/s (-93 J/s, rounding up the cipher). - 93 J/s is Power, equivalent to - 93 W.
Balance of energy:
To know the balance of the energy (I) we use the next formula:
I = P/A
Where I is the energy balance, P is the flux of energy by radiation and A is the area.
Introducing magnitudes:
I = - 93 W/1.9 m^2 = - 48.77 W/m^2 (-49 W/m^2, rounding up the cipher).
The negative sign means that the energy is being diffused from higher to lower temperature. The energy balance is 49 W/m^2.
The
loss of energy is – 93 J/s and the intensity of the energy radiated is
-49 W/m^2; something that does not coincide with reality.
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